Random model approach for QTL mapping in half-sib families
نویسندگان
چکیده
منابع مشابه
On the use of linear regression and maximum likelihood for QTL mapping in half-sib designs.
Methods of identification of quantitative trait loci (QTL) using a half-sib design are generally based on least-squares or maximum likelihood approaches. These methods differ in the genetical model considered and in the information used. Despite these differences, the power of the two methods in a daughter design in very similar. Using an analogy with a one-way analysis of variance, we propose ...
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In the goal of genetic improvement of livestock by marker assisted selection, we aim at reconstructing the haplotypes of sires from their offspring. We reformulated this problem into a binary weighted constraint satisfaction problem. Our results showed these problems have a small treewidth and can be solved optimally, improving haplotype reconstruction compared to previous approaches especially...
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Maximum likelihood methods for the estimation of linkage disequilibrium between biallelic DNA-markers in half-sib families (half-sib method) are developed for single and multifamily situations. Monte Carlo computer simulations were carried out for a variety of scenarios regarding sire genotypes, linkage disequilibrium, recombination fraction, family size, and number of families. A double hetero...
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Nineteen linkage groups containing a total of 52 markers have been identified in the sheep genome after typing large paternal half-sib families. The linkage groups range in size from 2 markers showing no recombination to a group containing 6 markers covering approximately 30 cM of the sheep genome. Thirteen of the groups have been assigned to a sheep chromosome. Three groups contain markers fro...
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ژورنال
عنوان ژورنال: Genetics Selection Evolution
سال: 1999
ISSN: 1297-9686
DOI: 10.1186/1297-9686-31-4-319